2ZOQ
Structural dissection of human mitogen-activated kinase ERK1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Mitogen-activated protein kinase 3 | polymer | 382 | 43527.8 | 2 | UniProt (P27361) Pfam (PF00069) | Homo sapiens (human) | Extracellular signal-regulated kinase 1, ERK-1, Insulin-stimulated MAP2 kinase, MAP kinase 1, MAPK 1, p44-ERK1, ERT2, p44-MAPK, Microtubule-associated protein 2 kinase |
| 2 | C, F (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 3 | D, G (A, B) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 4 | E, H (A, B) | (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL | non-polymer | 392.1 | 2 | Chemie (5ID) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 314 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 379 (UniProt: P27361)
| PDB | External Database | Details |
|---|---|---|
| Leu -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 87055.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1022.4 | |
| All* | Total formula weight | 88077.9 |
