2ZOQ
Structural dissection of human mitogen-activated kinase ERK1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Mitogen-activated protein kinase 3 | polymer | 382 | 43527.8 | 2 | UniProt (P27361) Pfam (PF00069) | Homo sapiens (human) | Extracellular signal-regulated kinase 1, ERK-1, Insulin-stimulated MAP2 kinase, MAP kinase 1, MAPK 1, p44-ERK1, ERT2, p44-MAPK, Microtubule-associated protein 2 kinase |
| 2 | C, F (A, B) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 3 | D, G (A, B) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) PubChem (923) | |||
| 4 | E, H (A, B) | (2R,3R,4S,5R)-2-(4-AMINO-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL)-5-(HYDROXYMETHYL)TETRAHYDROFURAN-3,4-DIOL | non-polymer | 392.1 | 2 | Chemie (5ID) PubChem (16760523) PubChem (1830) PubChem (23919584) PubChem (25880707) PubChem (26248662) PubChem (35028380) PubChem (97297) PubChem (46875276) PubChem (51386958) PubChem (51537014) PubChem (45039587) PubChem (59583554) PubChem (59583625) PubChem (6419781) PubChem (9886793) PubChem (14221929) PubChem (134695308) | |||
| 5 | I, J (A, B) | water | water | 18.0 | 314 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 379 (UniProt: P27361)
| PDB | External Database | Details |
|---|---|---|
| Leu -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 87055.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1022.4 | |
| All* | Total formula weight | 88077.9 |
