2ZNT
Crystal structure of the ligand-binding core of the human ionotropic glutamate receptor, GluR5, in complex with a novel selective agonist, dysiherbaine
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Glutamate receptor, ionotropic kainate 1 | polymer | 256 | 29093.4 | 1 | UniProt (P39086) Pfam (PF10613) Pfam (PF00060) In PDB | Homo sapiens (Human) | Glutamate receptor 5, GluR-5, GluR5, Excitatory amino acid receptor 3, EAA3, GluR5 ligand-binding core |
2 | A | (2R,3aR,6S,7R,7aR)-2-[(2S)-2-amino-2-carboxyethyl]-6-hydroxy-7-(methylamino)hexahydro-2H-furo[3,2-b]pyran-2-carboxylic acid | non-polymer | 304.3 | 1 | Chemie (DYH) | |||
3 | A | BETA-MERCAPTOETHANOL | non-polymer | 78.1 | 5 | Chemie (BME) | |||
4 | water | water | 18.0 | 225 | Chemie (HOH) |
Sequence modifications
A: 415 - 529 (UniProt: P39086)
A: 652 - 790 (UniProt: P39086)
A: 652 - 790 (UniProt: P39086)
PDB | External Database | Details |
---|---|---|
Gly 600 | - | linker |
Thr 601 | - | linker |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 29093.4 | |
Non-Polymers* | Number of molecules | 6 |
Total formula weight | 695.0 | |
All* | Total formula weight | 29788.4 |