2ZM1
Crystal structure of imidazo pyrazin 1 bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Proto-oncogene tyrosine-protein kinase LCK | polymer | 285 | 33065.6 | 1 | UniProt (P06239) Pfam (PF07714) In PDB | Homo sapiens (Human) | p56-LCK, Lymphocyte cell-specific protein-tyrosine kinase, LSK, T cell-specific protein-tyrosine kinase |
2 | A | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
3 | A | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
4 | A | N-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-amine | non-polymer | 320.8 | 1 | Chemie (KSF) | |||
5 | water | water | 18.0 | 289 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 33065.6 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 591.0 | |
All* | Total formula weight | 33656.6 |