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2ZM1

Crystal structure of imidazo pyrazin 1 bound to the kinase domain of human LCK, (auto-phosphorylated on TYR394)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1AProto-oncogene tyrosine-protein kinase LCKpolymer28533065.61UniProt (P06239)
Pfam (PF07714)
In PDB
Homo sapiens (Human)p56-LCK, Lymphocyte cell-specific protein-tyrosine kinase, LSK, T cell-specific protein-tyrosine kinase
2ASULFATE IONnon-polymer96.12Chemie (SO4)
3ADIMETHYL SULFOXIDEnon-polymer78.11Chemie (DMS)
4AN-(2-chlorophenyl)-5-phenylimidazo[1,5-a]pyrazin-8-aminenon-polymer320.81Chemie (KSF)
5waterwater18.0289Chemie (HOH)
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains1
Total formula weight33065.6
Non-Polymers*Number of molecules4
Total formula weight591.0
All*Total formula weight33656.6
*Water molecules are not included.

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PDB entries from 2024-07-17

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