2Z82
Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Toll-like receptor 2, Variable lymphocyte receptor B | polymer | 549 | 61973.0 | 1 | UniProt (Q9QUN7) UniProt (Q4G1L2) Pfam (PF13516) Pfam (PF13855) | Mus musculus (house mouse inshore hagfish) | CD282 antigen |
| 2 | B (B) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 3 | C (C) | alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G62182OO) | |||
| 4 | D (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 5 | E (A) | (2R)-3-{[(2R)-2-AMINO-3-HYDROXYPROPYL]THIO}PROPANE-1,2-DIYL DIHEXADECANOATE | non-polymer | 658.1 | 1 | Chemie (PDJ) | |||
| 6 | F (A) | water | water | 18.0 | 86 | Chemie (HOH) |
Sequence modifications
A: 27 - 506 (UniProt: Q9QUN7)
A: 509 - 575 (UniProt: Q4G1L2)
| PDB | External Database | Details |
|---|---|---|
| Ser 507 | - | linker |
| Arg 508 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 61973.0 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1010.9 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 879.3 | |
| All* | Total formula weight | 63863.2 |
