2Z6J
Crystal Structure of S. pneumoniae Enoyl-Acyl Carrier Protein Reductase (FabK) in Complex with an Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Trans-2-enoyl-ACP reductase II | polymer | 332 | 35289.4 | 2 | UniProt (Q9FBC5) Pfam (PF03060) In PDB | Streptococcus pneumoniae | Enoyl-Acyl-carrier-protein, reductase |
| 2 | A, B | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
| 3 | A, B | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 2 | Chemie (FMN) | |||
| 4 | A, B | 2-(4-(2-((3-(5-(PYRIDIN-2-YLTHIO)THIAZOL-2-YL)UREIDO)METHYL)-1H-IMIDAZOL-4-YL)PHENOXY)ACETIC ACID | non-polymer | 482.5 | 2 | Chemie (TUI) | |||
| 5 | A | (4S)-2-METHYL-2,4-PENTANEDIOL | non-polymer | 118.2 | 1 | Chemie (MPD) | |||
| 6 | water | water | 18.0 | 72 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 324 (UniProt: Q9FBC5)
| PDB | External Database | Details |
|---|---|---|
| Leu 325 | - | expression tag |
| Glu 326 | - | expression tag |
| His 327 | - | expression tag |
| His 328 | - | expression tag |
| His 329 | - | expression tag |
| His 330 | - | expression tag |
| His 331 | - | expression tag |
| His 332 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70578.8 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 2156.2 | |
| All* | Total formula weight | 72735.1 |
