2Z66

Crystal structure of the VT3 hybrid of human TLR4 and hagfish VLRB.61

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	Variable lymphocyte receptor B, Toll-like receptor 4	polymer	306	34364.0	4	UniProt (Q4G1L2) UniProt (O00206) Pfam (PF01462) Pfam (PF13855) Pfam (PF13516)	Eptatretus burgeri (inshore hagfish human)	hToll, CD284 antigen
2	E, I, M, Q (E, I, M, Q)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	4	In PDB GlyTouCan (G15407YE)
3	F, H, J, L, N... (F, H, J, L, N...)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	8	In PDB GlyTouCan (G42666HT)
4	G, K, O, S (G, K, O, S)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose	branched		732.7	4	In PDB GlyTouCan (G86566TX)
5	U, V, W, X (A, B, C, D)	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
6	AA, BA, Y, Z (C, D, A, B)	water	water		18.0	472	Chemie (HOH)

Sequence modifications

A, B, C, D: 24 - 82 (UniProt: Q4G1L2)
A, B, C, D: 383 - 627 (UniProt: O00206)

PDB	External Database	Details
Ser 83	-	SEE REMARK 999
Ser 84	-	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	137456.0
Branched	Number of molecules	16
	Total formula weight	8672.1
Non-Polymers*	Number of molecules	4
	Total formula weight	384.3
All*	Total formula weight	146512.4

*Water molecules are not included.