2Z65
Crystal structure of the human TLR4 TV3 hybrid-MD-2-Eritoran complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Toll-like receptor 4, Variable lymphocyte receptor B | polymer | 276 | 31141.7 | 2 | UniProt (O00206) UniProt (Q4G1L2) Pfam (PF13855) Pfam (PF12799) | Homo sapiens (human inshore hagfish) | hToll, CD284 antigen(human) |
| 2 | C, D (C, D) | Lymphocyte antigen 96 | polymer | 140 | 16184.8 | 2 | UniProt (Q9Y6Y9) Pfam (PF02221) | Homo sapiens (human) | MD-2 protein, ESOP-1 |
| 3 | E (E) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 4 | F, G, H, I, J (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 5 | K, L (C, D) | 3-O-DECYL-2-DEOXY-6-O-{2-DEOXY-3-O-[(3R)-3-METHOXYDECYL]-6-O-METHYL-2-[(11Z)-OCTADEC-11-ENOYLAMINO]-4-O-PHOSPHONO-BETA-D-GLUCOPYRANOSYL}-2-[(3-OXOTETRADECANOYL)AMINO]-1-O-PHOSPHONO-ALPHA-D-GLUCOPYRANOSE | non-polymer | 1313.7 | 2 | Chemie (E55) PubChem (9941865) PubChem (10080126) PubChem (10170989) PubChem (44547433) PubChem (58675422) PubChem (58767051) PubChem (59115774) PubChem (59080379) PubChem (60127991) PubChem (88561736) PubChem (89243091) PubChem (3083506) PubChem (91049425) PubChem (91286554) PubChem (91460055) PubChem (53398664) PubChem (6602298) PubChem (122173793) PubChem (6912404) PubChem (10192393) PubChem (11240371) PubChem (139507925) PubChem (58675438) PubChem (59806266) PubChem (88561915) PubChem (91013214) PubChem (91013446) PubChem (137326959) | |||
| 6 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 163 | Chemie (HOH) |
Sequence modifications
A, B: 27 - 228 (UniProt: O00206)
A, B: 231 - 302 (UniProt: Q4G1L2)
| PDB | External Database | Details |
|---|---|---|
| Lys 229 | - | SEE REMARK 999 |
| Glu 230 | - | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 94653.0 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 586.5 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 3733.4 | |
| All* | Total formula weight | 98972.9 |
