2Z65
Crystal structure of the human TLR4 TV3 hybrid-MD-2-Eritoran complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Toll-like receptor 4, Variable lymphocyte receptor B | polymer | 276 | 31141.7 | 2 | UniProt (O00206) UniProt (Q4G1L2) Pfam (PF13855) Pfam (PF12799) Pfam (PF11921) | Homo sapiens (human inshore hagfish) | hToll, CD284 antigen(human) |
| 2 | C, D (C, D) | Lymphocyte antigen 96 | polymer | 140 | 16184.8 | 2 | UniProt (Q9Y6Y9) Pfam (PF02221) | Homo sapiens (human) | MD-2 protein, ESOP-1 |
| 3 | E (E) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 4 | F, G, H, I, J (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 5 | Chemie (NAG) | |||
| 5 | K, L (C, D) | 3-O-DECYL-2-DEOXY-6-O-{2-DEOXY-3-O-[(3R)-3-METHOXYDECYL]-6-O-METHYL-2-[(11Z)-OCTADEC-11-ENOYLAMINO]-4-O-PHOSPHONO-BETA-D-GLUCOPYRANOSYL}-2-[(3-OXOTETRADECANOYL)AMINO]-1-O-PHOSPHONO-ALPHA-D-GLUCOPYRANOSE | non-polymer | 1313.7 | 2 | Chemie (E55) | |||
| 6 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 163 | Chemie (HOH) |
Sequence modifications
A, B: 27 - 228 (UniProt: O00206)
A, B: 231 - 302 (UniProt: Q4G1L2)
| PDB | External Database | Details |
|---|---|---|
| Lys 229 | - | SEE REMARK 999 |
| Glu 230 | - | SEE REMARK 999 |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 94653.0 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 586.5 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 3733.4 | |
| All* | Total formula weight | 98972.9 |
