2YQ7
Structure of Bcl-xL bound to BimLOCK
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | BCL-2-LIKE PROTEIN 1 | polymer | 158 | 17918.0 | 1 | UniProt (Q07817) Pfam (PF02180) Pfam (PF00452) | HOMO SAPIENS (HUMAN) | BCL-XL, BCL2-L-1, APOPTOSIS REGULATOR BCL-X |
| 2 | B (B) | BCL-2-LIKE PROTEIN 11 | polymer | 20 | 2213.5 | 1 | UniProt (O43521) Pfam (PF08945) | HOMO SAPIENS | BIM BETA 5, BCL2-L-11, BCL2-INTERACTING MEDIATOR OF CELL DEATH, BIMEL |
| 3 | C (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 120 | Chemie (HOH) |
Sequence modifications
A: 1 - 26 (UniProt: Q07817)
B: 147 - 164 (UniProt: O43521)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Pro -3 | - | expression tag |
| Leu -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ace 146 | - | acetylation |
| Glu 154 | Arg 154 | engineered mutation |
| Lys 158 | Glu 158 | engineered mutation |
| Nh2 165 | - | amidation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 20131.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 92.1 | |
| All* | Total formula weight | 20223.5 |
