2YME
Crystal structure of a mutant binding protein (5HTBP-AChBP) in complex with granisetron
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E... (A, B, C, D, E...) | SOLUBLE ACETYLCHOLINE RECEPTOR | polymer | 205 | 23343.1 | 10 | UniProt (Q8WSF8) Pfam (PF02931) | APLYSIA CALIFORNICA (CALIFORNIA SEA HARE) | ACHBP |
| 2 | BA, EA, HA, K, N... (H, I, J, A, B...) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 9 | Chemie (NAG) | |||
| 3 | CA, FA, IA, L, O... (H, I, J, A, B...) | 1-methyl-N-[(1R,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-yl]indazole-3-carboxamide | non-polymer | 312.4 | 10 | Chemie (CWB) | |||
| 4 | AA, DA, M, R, V (G, H, A, C, E) | PHOSPHATE ION | non-polymer | 95.0 | 5 | Chemie (PO4) | |||
| 5 | GA (I) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | JA, KA, LA, MA, NA... (A, B, C, D, E...) | water | water | 18.0 | 1251 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E, F, G, H, I, J: 1 - 205 (UniProt: Q8WSF8)
| PDB | External Database | Details |
|---|---|---|
| Val 41 | Ala 60 | conflict |
| Trp 53 | Tyr 72 | engineered mutation |
| Arg 55 | Gln 74 | conflict |
| Val 136 | Ala 155 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 233431.4 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 5612.8 | |
| All* | Total formula weight | 239044.2 |
