2YKJ
Tricyclic series of Hsp90 inhibitors
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HEAT SHOCK PROTEIN HSP 90-ALPHA | polymer | 209 | 23361.5 | 1 | UniProt (P07900) Pfam (PF13589) | HOMO SAPIENS (HUMAN) | HEAT SHOCK 86 KDA, HSP 86, HSP86, RENAL CARCINOMA ANTIGEN NY-REN-38, HSP90 |
| 2 | B (A) | 2-AMINO-N-[4-(3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)--9H-FLUOREN-9-YL]-ISONICOTINAMIDE | non-polymer | 418.4 | 1 | Chemie (YKJ) | |||
| 3 | C (A) | water | water | 18.0 | 321 | Chemie (HOH) |
Sequence modifications
A: 18 - 223 (UniProt: P07900)
| PDB | External Database | Details |
|---|---|---|
| Gly 15 | - | expression tag |
| His 16 | - | expression tag |
| Met 17 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 23361.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 418.4 | |
| All* | Total formula weight | 23779.9 |
