2YFX
Structure of L1196M Mutant Anaplastic Lymphoma Kinase in Complex with Crizotinib
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | TYROSINE-PROTEIN KINASE RECEPTOR | polymer | 327 | 36927.4 | 1 | UniProt (B6EXY4) Pfam (PF07714) UniProt (by SIFTS) (Q9UM73) | HOMO SAPIENS (HUMAN) | ANAPLASTIC LYMPHOMA KINASE |
| 2 | B (A) | 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine | non-polymer | 450.3 | 1 | Chemie (VGH) | |||
| 3 | C (A) | water | water | 18.0 | 237 | Chemie (HOH) |
Sequence modifications
A: 1093 - 1411 (UniProt: B6EXY4)
| PDB | External Database | Details |
|---|---|---|
| Met 1085 | - | expression tag |
| Ala 1086 | - | expression tag |
| His 1087 | - | expression tag |
| His 1088 | - | expression tag |
| His 1089 | - | expression tag |
| His 1090 | - | expression tag |
| His 1091 | - | expression tag |
| His 1092 | - | expression tag |
| Met 1196 | Leu 208 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36927.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 450.3 | |
| All* | Total formula weight | 37377.7 |
