2YDI

Discovery of Checkpoint Kinase Inhibitor AZD7762 by Structure Based Design and Optimization of Thiophene Carboxamide Ureas

Entity

Chain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
ASERINE/THREONINE-PROTEIN KINASE CHK1polymer28933043.01
UniProt (O14757)
Pfam (PF00069)
HOMO SAPIENS (HUMAN)@PDBjCHK1 CHECKPOINT KINASE
SULFATE IONnon-polymer96.11
5-[4-(2-DIMETHYLAMINOETHYLOXY)PHENYL]-2-UREIDO-THIOPHENE-3-CARBOXAMIDEnon-polymer348.41
waterwater18.0332

Sequence viewer

Contents of the asymmetric unit

PolymersNumber of chains1
Total molecular weight33043.0
Non-Polymers*Number of molecules2
Total molecular weight444.5
All*Total molecular weight33487.5
*Water molecules are not included.