2YD9

Crystal structure of the N-terminal Ig1-3 module of Human Receptor Protein Tyrosine Phosphatase Sigma

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE S	polymer	304	33261.6	1	UniProt (Q13332) Pfam (PF07679) Pfam (PF13927)	HOMO SAPIENS (HUMAN)	R-PTP-S, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE SIGMA R-PTP-SIGMA, RECEPTOR PROTEIN TYROSINE PHOSPHATASE SIGMA
2	B, C, D, E (A)	CHLORIDE ION	non-polymer		35.5	4	Chemie (CL)
3	F, G, H, I (A)	IODIDE ION	non-polymer		126.9	4	Chemie (IOD)
4	J, K (A)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	2	Chemie (NAG)
5	L (A)	2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL	non-polymer		282.3	1	Chemie (B3P)
6	M (A)	water	water		18.0	20	Chemie (HOH)

Sequence modifications

A: 30 - 321 (UniProt: Q13332)

PDB	External Database	Details
Glu 27	-	expression tag
Thr 28	-	expression tag
Gly 29	-	expression tag
Gln 228	Arg 228	engineered mutation
Asn 229	Arg 229	engineered mutation
Gly 322	-	expression tag
Thr 323	-	expression tag
Lys 324	-	expression tag
His 325	-	expression tag
His 326	-	expression tag
His 327	-	expression tag
His 328	-	expression tag
His 329	-	expression tag
His 330	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	33261.6
Non-Polymers*	Number of molecules	11
	Total formula weight	1374.2
All*	Total formula weight	34635.7

*Water molecules are not included.