2YCX

TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND ANTAGONIST CYANOPINDOLOL

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	BETA-1 ADRENERGIC RECEPTOR	polymer	313	35752.6	2	UniProt (P07700) Pfam (PF00001)	MELEAGRIS GALLOPAVO (TURKEY)	BETA-1 ADRENORECEPTOR, BETA-1 ADRENOCEPTOR, BETA-T
2	C, D (A, B)	Cyanopindolol	non-polymer		287.4	2	Chemie (P32)
3	E, F, G (B)	octyl 1-thio-beta-D-glucopyranoside	non-polymer		308.4	3	Chemie (SOG)

Sequence modifications

A, B: 33 - 367 (UniProt: P07700)

PDB	External Database	Details
Met 31	-	expression tag
Gly 32	-	expression tag
Ser 68	Arg 68	engineered mutation
Val 90	Met 90	engineered mutation
Leu 116	Cys 116	engineered mutation
Ala 227	Tyr 227	engineered mutation
-	Cys 244	deletion
-	Glu 245	deletion
-	Gly 246	deletion
-	Arg 247	deletion
-	Phe 248	deletion
-	Tyr 249	deletion
-	Gly 250	deletion
-	Ser 251	deletion
-	Gln 252	deletion
-	Glu 253	deletion
-	Gln 254	deletion
-	Pro 255	deletion
-	Gln 256	deletion
-	Pro 257	deletion
-	Pro 258	deletion
-	Pro 259	deletion
-	Leu 260	deletion
-	Pro 261	deletion
-	Gln 262	deletion
-	His 263	deletion
-	Gln 264	deletion
-	Pro 265	deletion
-	Ile 266	deletion
-	Leu 267	deletion
-	Gly 268	deletion
-	Asn 269	deletion
-	Gly 270	deletion
-	Arg 271	deletion
-	Thr 277	deletion
-	Ser 278	deletion
Leu 282	Ala 282	engineered mutation
Ala 327	Phe 327	engineered mutation
Met 338	Phe 338	engineered mutation
Ala 358	Cys 358	engineered mutation
His 368	-	expression tag
His 369	-	expression tag
His 370	-	expression tag
His 371	-	expression tag
His 372	-	expression tag
His 373	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	71505.2
Non-Polymers*	Number of molecules	5
	Total formula weight	1500.0
All*	Total formula weight	73005.2

*Water molecules are not included.