2YA6

Crystal structure of Streptococcus pneumoniae NanA (TIGR4) in complex with DANA

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	NEURAMINIDASE A	polymer	493	55346.7	2	UniProt (B2DJD9) UniProt (by SIFTS) (P62575)	STREPTOCOCCUS PNEUMONIAE	NANA
2	C, H (A, B)	2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID	non-polymer		291.3	2	Chemie (DAN) PubChem (1553) PubChem (65309) PubChem (196123) PubChem (440392) PubChem (44299597) PubChem (44305374) PubChem (44314809) PubChem (44353094) PubChem (44387099) PubChem (44629965) PubChem (492456) PubChem (49819354) PubChem (57673682) PubChem (50986297) PubChem (68019401) PubChem (71299570) PubChem (71312796) PubChem (93616863) PubChem (13728878) PubChem (101008065) PubChem (5329058) PubChem (102094437) PubChem (132002898) PubChem (15956564) PubChem (133688885)
3	D, F, G, J, K (A, B)	FORMIC ACID	non-polymer		46.0	5	Chemie (FMT) PubChem (284)
4	E, I (A, B)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL) PubChem (312)
5	L, M (A, B)	water	water		18.0	585	Chemie (HOH)

Sequence modifications

A, B: 303 - 777 (UniProt: B2DJD9)

PDB	External Database	Details
Ala 285	-	expression tag
His 286	-	expression tag
His 287	-	expression tag
His 288	-	expression tag
His 289	-	expression tag
His 290	-	expression tag
His 291	-	expression tag
Ser 292	-	expression tag
Ser 293	-	expression tag
Gly 294	-	expression tag
Leu 295	-	expression tag
Glu 296	-	expression tag
Val 297	-	expression tag
Leu 298	-	expression tag
Phe 299	-	expression tag
Gln 300	-	expression tag
Gly 301	-	expression tag
Pro 302	-	expression tag
Lys 440	Glu 417	SEE REMARK 999
Asp 584	Asn 561	SEE REMARK 999

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	110693.4
Non-Polymers*	Number of molecules	9
	Total formula weight	883.5
All*	Total formula weight	111576.9

*Water molecules are not included.