2Y8Q
Structure of the regulatory fragment of mammalian AMPK in complex with one ADP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 5'-AMP-ACTIVATED PROTEIN KINASE CATALYTIC SUBUNIT ALPHA-1 | polymer | 173 | 19486.8 | 1 | UniProt (P54645) Pfam (PF16579) | RATTUS NORVEGICUS (NORWAY RAT) | AMPK SUBUNIT ALPHA-1 |
| 2 | B (B) | 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT BETA-2 | polymer | 87 | 10040.8 | 1 | UniProt (O43741) Pfam (PF04739) | HOMO SAPIENS (HUMAN) | AMPK SUBUNIT BETA-2 |
| 3 | C (E) | 5'-AMP-ACTIVATED PROTEIN KINASE SUBUNIT GAMMA-1 | polymer | 330 | 37434.1 | 1 | UniProt (P80385) Pfam (PF00571) | RATTUS NORVEGICUS (NORWAY RAT) | AMPK GAMMA1, AMPK SUBUNIT GAMMA-1, AMPKG |
| 4 | D (E) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 5 | E (E) | ADENOSINE MONOPHOSPHATE | non-polymer | 347.2 | 1 | Chemie (AMP) PubChem (224) PubChem (34768) PubChem (83862) PubChem (446048) PubChem (515384) PubChem (638042) PubChem (5316444) PubChem (5742864) PubChem (12163610) PubChem (12358355) PubChem (16397049) PubChem (16760266) PubChem (40467049) PubChem (40469468) PubChem (44348067) PubChem (45358029) PubChem (46874558) PubChem (40459109) PubChem (46875232) PubChem (177678969) PubChem (6083) PubChem (1549371) PubChem (92144436) PubChem (57358045) PubChem (57879893) PubChem (57879902) PubChem (12358354) PubChem (122197642) PubChem (162290139) PubChem (162946266) PubChem (171699505) | |||
| 6 | F, G, H (A, B, E) | water | water | 18.0 | 56 | Chemie (HOH) |
Sequence modifications
A: 396 - 544 (UniProt: P54645)
B: 187 - 270 (UniProt: O43741)
| PDB | External Database | Details |
|---|---|---|
| Met 378 | - | expression tag |
| Ser 379 | - | expression tag |
| His 380 | - | expression tag |
| His 381 | - | expression tag |
| His 382 | - | expression tag |
| His 383 | - | expression tag |
| His 384 | - | expression tag |
| His 385 | - | expression tag |
| Ser 386 | - | expression tag |
| Gly 387 | - | expression tag |
| Leu 388 | - | expression tag |
| Val 389 | - | expression tag |
| Pro 390 | - | expression tag |
| Arg 391 | - | expression tag |
| Gly 392 | - | expression tag |
| Ser 393 | - | expression tag |
| Met 394 | - | expression tag |
| Ala 395 | - | expression tag |
| Asn 545 | - | expression tag |
| Ser 546 | - | expression tag |
| Cys 547 | - | expression tag |
| Thr 548 | - | expression tag |
| Val 549 | - | expression tag |
| Asn 550 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 186 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 66961.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 774.4 | |
| All* | Total formula weight | 67736.2 |
