2Y7X
The discovery of potent and long-acting oral factor Xa inhibitors with tetrahydroisoquinoline and benzazepine P4 motifs
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | ACTIVATED FACTOR XA HEAVY CHAIN | polymer | 254 | 28550.6 | 1 | UniProt (P00742) Pfam (PF00089) In PDB | HOMO SAPIENS (HUMAN) | COAGULATION FACTOR X, STUART FACTOR, STUART-PROWER FACTOR |
| 2 | B | FACTOR X LIGHT CHAIN | polymer | 134 | 15210.8 | 1 | UniProt (P00742) Pfam (PF00594) Pfam (PF00008) Pfam (PF14670) In PDB | HOMO SAPIENS (HUMAN) | COAGULATION FACTOR X, STUART FACTOR, STUART-PROWER FACTOR |
| 3 | A | 6-CHLORO-N-[(3S)-1-(5-FLUORO-1,2,3,4-TETRAHYDROISOQUINOLIN-6-YL)-2-OXO-PYRROLIDIN-3-YL]NAPHTHALENE-2-SULFONAMIDE | non-polymer | 473.9 | 1 | Chemie (MZA) | |||
| 4 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 6 | water | water | 18.0 | 245 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43761.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 538.3 | |
| All* | Total formula weight | 44299.7 |
