2Y6W

Structure of a Bcl-w dimer

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	BCL-2-LIKE PROTEIN 2	polymer	177	19505.7	2	UniProt (Q92843) Pfam (PF02180) Pfam (PF00452)	HOMO SAPIENS (HUMAN)	BCL-W, BCL2-L-2, APOPTOSIS REGULATOR BCL-W
2	C, D, E, G, H (A, B)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	5	Chemie (PEG)
3	F (B)	TRIETHYLENE GLYCOL	non-polymer		150.2	1	Chemie (PGE)
4	I, J (A, B)	water	water		18.0	154	Chemie (HOH)

Sequence modifications

A, B: 1 - 164 (UniProt: Q92843)

PDB	External Database	Details
Met -12	-	expression tag
Gly -11	-	expression tag
Ser -10	-	expression tag
His -9	-	expression tag
His -8	-	expression tag
His -7	-	expression tag
His -6	-	expression tag
His -5	-	expression tag
His -4	-	expression tag
Gly -3	-	expression tag
Ala -2	-	expression tag
Arg -1	-	expression tag
Gln 0	-	expression tag
Ser 29	Cys 29	engineered mutation
Glu 128	Ala 128	engineered mutation
Arg 133	Gln 133	variant

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	39011.4
Non-Polymers*	Number of molecules	6
	Total formula weight	680.8
All*	Total formula weight	39692.2

*Water molecules are not included.