2Y5K
Orally active aminopyridines as inhibitors of tetrameric fructose 1,6- bisphosphatase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | FRUCTOSE-1,6-BISPHOSPHATASE 1 | polymer | 338 | 36859.4 | 4 | UniProt (P09467) Pfam (PF00316) Pfam (PF18913) | HOMO SAPIENS (HUMAN) | D-FRUCTOSE-1,6-BISPHOSPHATE 1-PHOSPHOHYDROLASE 1, FBPASE 1 |
| 2 | E, F, G, H (A, B, C, D) | 1-[5-(2-METHOXYETHYL)-4-METHYL-THIOPHEN-2-YL]SULFONYL-3-[4-METHOXY-6-(METHYLCARBAMOYLAMINO)PYRIDIN-2-YL]UREA | non-polymer | 457.5 | 4 | Chemie (YCU) | |||
| 3 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 1003 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 0 - 337 (UniProt: P09467)
| PDB | External Database | Details |
|---|---|---|
| Lys 217 | Arg 218 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 147437.7 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1830.1 | |
| All* | Total formula weight | 149267.8 |
