2Y41

Structure of Isopropylmalate dehydrogenase from Thermus thermophilus - complex with IPM and MN

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	3-ISOPROPYLMALATE DEHYDROGENASE	polymer	359	38398.9	2	UniProt (Q5SIY4) Pfam (PF00180)	THERMUS THERMOPHILUS	ISOPROPYLMALATE DEHYDROGENASE, 3-IPM-DH, BETA-IPM DEHYDROGENASE, IMDH, IPMDH
2	C, E (A, B)	3-ISOPROPYLMALIC ACID	non-polymer		176.2	2	Chemie (IPM)
3	D, F, G, H (A, B)	MANGANESE (II) ION	non-polymer		54.9	4	Chemie (MN)
4	I, J (A, B)	water	water		18.0	203	Chemie (HOH)

Sequence modifications

A, B: 1 - 345 (UniProt: Q5SIY4)

PDB	External Database	Details
Met -2	-	expression tag
Ala -1	-	expression tag
Ser 0	-	expression tag
Ala 346	-	expression tag
Ala 347	-	expression tag
Ala 348	-	expression tag
Leu 349	-	expression tag
Glu 350	-	expression tag
His 351	-	expression tag
His 352	-	expression tag
His 353	-	expression tag
His 354	-	expression tag
His 355	-	expression tag
His 356	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	76797.8
Non-Polymers*	Number of molecules	6
	Total formula weight	572.1
All*	Total formula weight	77369.9

*Water molecules are not included.