2Y00
TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND PARTIAL AGONIST DOBUTAMINE (CRYSTAL DOB92)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | BETA-1 ADRENERGIC RECEPTOR | polymer | 315 | 35940.8 | 2 | UniProt (P07700) Pfam (PF00001) | MELEAGRIS GALLOPAVO (TURKEY) | BETA-1 ADRENORECEPTOR, BETA-1 ADRENOCEPTOR, BETA-T |
| 2 | C, D, L, M (A, B) | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 4 | Chemie (Y01) PubChem (16219150) PubChem (22210610) PubChem (45489984) PubChem (57163942) PubChem (89891013) PubChem (99567468) PubChem (60078761) PubChem (124427194) PubChem (124897021) PubChem (124897020) PubChem (10005657) PubChem (130340716) PubChem (11969853) PubChem (73440805) PubChem (137392566) PubChem (137496323) PubChem (65082) PubChem (363416) PubChem (155804219) PubChem (99567469) PubChem (500055) PubChem (169132514) PubChem (124301053) PubChem (124302591) PubChem (124303794) PubChem (124421343) PubChem (124427195) PubChem (124914595) PubChem (124914596) PubChem (131705526) PubChem (137332121) PubChem (137496357) PubChem (146157332) PubChem (154929912) PubChem (13301926) PubChem (13301927) PubChem (155199678) PubChem (156327905) PubChem (156426247) PubChem (156516588) PubChem (166979870) PubChem (167024614) PubChem (169132513) PubChem (170117245) PubChem (172400028) | |||
| 3 | E, F, G, H, I... (A, B) | HEGA-10 | non-polymer | 379.5 | 10 | Chemie (2CV) PubChem (23653119) PubChem (49835947) | |||
| 4 | J, S (A, B) | DOBUTAMINE | non-polymer | 301.4 | 2 | Chemie (Y00) PubChem (36811) PubChem (667531) PubChem (688441) | |||
| 5 | K (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) PubChem (923) | |||
| 6 | T, U (A, B) | water | water | 18.0 | 38 | Chemie (HOH) |
Sequence modifications
A, B: 33 - 368 (UniProt: P07700)
| PDB | External Database | Details |
|---|---|---|
| Met 31 | - | expression tag |
| Gly 32 | - | expression tag |
| Ser 68 | Arg 68 | engineered mutation |
| Val 90 | Met 90 | engineered mutation |
| Leu 116 | Cys 116 | engineered mutation |
| Ala 227 | Tyr 227 | engineered mutation |
| - | Cys 244 | deletion |
| - | Glu 245 | deletion |
| - | Gly 246 | deletion |
| - | Arg 247 | deletion |
| - | Phe 248 | deletion |
| - | Tyr 249 | deletion |
| - | Gly 250 | deletion |
| - | Ser 251 | deletion |
| - | Gln 252 | deletion |
| - | Glu 253 | deletion |
| - | Gln 254 | deletion |
| - | Pro 255 | deletion |
| - | Gln 256 | deletion |
| - | Pro 257 | deletion |
| - | Pro 258 | deletion |
| - | Pro 259 | deletion |
| - | Leu 260 | deletion |
| - | Pro 261 | deletion |
| - | Gln 262 | deletion |
| - | His 263 | deletion |
| - | Gln 264 | deletion |
| - | Pro 265 | deletion |
| - | Ile 266 | deletion |
| - | Leu 267 | deletion |
| - | Gly 268 | deletion |
| - | Asn 269 | deletion |
| - | Gly 270 | deletion |
| - | Arg 271 | deletion |
| Leu 282 | Ala 282 | engineered mutation |
| Ala 327 | Phe 327 | engineered mutation |
| Met 338 | Phe 338 | engineered mutation |
| Ala 358 | Cys 358 | engineered mutation |
| His 369 | - | expression tag |
| His 370 | - | expression tag |
| His 371 | - | expression tag |
| His 372 | - | expression tag |
| His 373 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71881.6 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 6367.5 | |
| All* | Total formula weight | 78249.1 |
