2XX7
Crystal structure of 1-(4-(1-pyrrolidinylcarbonyl)phenyl)-3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazole in complex with the ligand binding domain of the Rat GluA2 receptor and glutamate at 2.2A resolution.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | GLUTAMATE RECEPTOR 2 | polymer | 291 | 32185.9 | 3 | UniProt (P19491) Pfam (PF10613) Pfam (PF00060) | RATTUS NORVEGICUS (NORWAY RAT) | GLUR-2, AMPA-SELECTIVE GLUTAMATE RECEPTOR 2, GLUR-B, GLUR-K2, GLUTAMATE RECEPTOR IONOTROPIC\,AMPA 2, GLUA2 |
| 2 | D, F, L (A, B, C) | GLUTAMIC ACID | non-polymer | 147.1 | 3 | Chemie (GLU) | |||
| 3 | E, G (A, B) | 1-[4-(1-PYRROLIDINYLCARBONYL)PHENYL]-3-(TRIFLUOROMETHYL)-4,5,6,7-TETRAHYDRO-1H-INDAZOLE | non-polymer | 363.4 | 2 | Chemie (1ND) | |||
| 4 | H (B) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 5 | I, J, K, M, N (B, C) | ZINC ION | non-polymer | 65.4 | 5 | Chemie (ZN) | |||
| 6 | O, P, Q (A, B, C) | water | water | 18.0 | 541 | Chemie (HOH) |
Sequence modifications
A, B, C: 3 - 117 (UniProt: P19491)
A, B, C: 120 - 262 (UniProt: P19491)
| PDB | External Database | Details |
|---|---|---|
| Met -28 | - | expression tag |
| Gly -27 | - | expression tag |
| Ser -26 | - | expression tag |
| Ser -25 | - | expression tag |
| His -24 | - | expression tag |
| His -23 | - | expression tag |
| His -22 | - | expression tag |
| His -21 | - | expression tag |
| His -20 | - | expression tag |
| His -19 | - | expression tag |
| Ser -18 | - | expression tag |
| Ser -17 | - | expression tag |
| Gly -16 | - | expression tag |
| Leu -15 | - | expression tag |
| Val -14 | - | expression tag |
| Pro -13 | - | expression tag |
| Arg -12 | - | expression tag |
| Gly -11 | - | expression tag |
| Ser -10 | - | expression tag |
| His -9 | - | expression tag |
| Met -8 | - | expression tag |
| Gly -7 | - | expression tag |
| Ser -6 | - | expression tag |
| Gly -5 | - | expression tag |
| Asn -4 | - | expression tag |
| Asp -3 | - | expression tag |
| Thr -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Arg 0 | - | expression tag |
| Gly 1 | - | expression tag |
| Ala 2 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 118 | - | linker |
| Thr 119 | - | linker |
| Ser 242 | Asn 775 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 96557.7 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1591.2 | |
| All* | Total formula weight | 98148.9 |
