2XWY
Structure of MK-3281, a Potent Non-Nucleoside Finger-Loop Inhibitor, in complex with the Hepatitis C Virus NS5B Polymerase
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | RNA-DIRECTED RNA POLYMERASE | polymer | 537 | 59772.7 | 1 | UniProt (P26663) Pfam (PF00998) | HEPATITIS C VIRUS | NS5B, P68 |
| 2 | B (A) | (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl)amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid | non-polymer | 475.6 | 1 | Chemie (IB8) | |||
| 3 | C, D (A) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 4 | E (A) | water | water | 18.0 | 130 | Chemie (HOH) |
Sequence modifications
A: 1 - 536 (UniProt: P26663)
| PDB | External Database | Details |
|---|---|---|
| Met 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 59772.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 585.5 | |
| All* | Total formula weight | 60358.2 |
