2XWE
X-RAY STRUCTURE OF ACID-BETA-GLUCOSIDASE WITH 5N,6S-(N'-(N-OCTYL)IMINO)-6-THIONOJIRIMYCIN IN THE ACTIVE SITE
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | GLUCOSYLCERAMIDASE | polymer | 505 | 56589.3 | 2 | UniProt (P04062) Pfam (PF02055) Pfam (PF17189) In PDB | HOMO SAPIENS (HUMAN) | ACID-BETA-GLUCOSIDASE, ALGLUCERASE, BETA-GLUCOCEREBROSIDASE, D-GLUCOSYL-N-ACYLSPHINGOSINE GLUCOHYDROLASE, IMIGLUCERASE |
| 2 | C, D | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 2 | In PDB GlyTouCan (G18638YB) | |||
| 3 | A, B | PHOSPHATE ION | non-polymer | 95.0 | 2 | Chemie (PO4) | |||
| 4 | A, B | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
| 5 | A, B | (3Z,5S,6R,7S,8R,8aS)-3-(octylimino)hexahydro[1,3]thiazolo[3,4-a]pyridine-5,6,7,8-tetrol | non-polymer | 332.5 | 2 | Chemie (AMF) | |||
| 6 | water | water | 18.0 | 474 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 497 (UniProt: P04062)
| PDB | External Database | Details |
|---|---|---|
| Glu -1 | - | expression tag |
| Phe 0 | - | expression tag |
| His 495 | Arg 514 | variant |
| Leu 498 | - | expression tag |
| Leu 499 | - | expression tag |
| Val 500 | - | expression tag |
| Asp 501 | - | expression tag |
| Thr 502 | - | expression tag |
| Met 503 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 113178.6 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1465.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 933.1 | |
| All* | Total formula weight | 115577.0 |
