2XS0
Linear binding motifs for JNK and for calcineurin antagonistically control the nuclear shuttling of NFAT4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | MITOGEN-ACTIVATED PROTEIN KINASE 8 | polymer | 386 | 44206.1 | 1 | UniProt (P45983) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | MAP KINASE 8, MAPK 8, STRESS-ACTIVATED PROTEIN KINASE JNK1, JNK1, C-JUN N-TERMINAL KINASE 1, JNK-46, STRESS-ACTIVATED PROTEIN KINASE 1 |
| 2 | B (B) | NUCLEAR FACTOR OF ACTIVATED T-CELLS, CYTOPLASMIC 3 | polymer | 14 | 1741.0 | 1 | UniProt (Q12968) | HOMO SAPIENS | NF-ATC3, T-CELL TRANSCRIPTION FACTOR NFAT4, NFATX |
| 3 | C (A) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 1 | Chemie (ANP) | |||
| 4 | D (A) | water | water | 18.0 | 18 | Chemie (HOH) |
Sequence modifications
A: 1 - 384 (UniProt: P45983)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Val 183 | Thr 183 | engineered mutation |
| Phe 185 | Tyr 185 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 45947.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 506.2 | |
| All* | Total formula weight | 46453.2 |
