2XR6
Crystal structure of the complex of the carbohydrate recognition domain of human DC-SIGN with pseudo trimannoside mimic.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | CD209 ANTIGEN | polymer | 170 | 19502.5 | 1 | UniProt (Q9NNX6) Pfam (PF00059) | HOMO SAPIENS (HUMAN) | DC-SIGN, DENDRITIC CELL-SPECIFIC ICAM-3-GRABBING NON-INTEGRIN 1, DC-SIGN1, C-TYPE LECTIN DOMAIN FAMILY 4 MEMBER L, CD209 |
| 2 | B, D (A) | alpha-D-mannopyranose | non-polymer | 180.2 | 2 | Chemie (MAN) | |||
| 3 | C (A) | dimethyl (1S,2S,4S,5S)-4,5-dihydroxycyclohexane-1,2-dicarboxylate | non-polymer | 232.2 | 1 | Chemie (07B) | |||
| 4 | E (A) | 2-AZIDOETHANOL | non-polymer | 87.1 | 1 | Chemie (AE9) | |||
| 5 | F, G, H (A) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 6 | I, J, K (A) | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 7 | L (A) | water | water | 18.0 | 166 | Chemie (HOH) |
Sequence modifications
A: 250 - 404 (UniProt: Q9NNX6)
| PDB | External Database | Details |
|---|---|---|
| Met 235 | - | expression tag |
| Ala 236 | - | expression tag |
| Ser 237 | - | expression tag |
| Trp 238 | - | expression tag |
| Ser 239 | - | expression tag |
| His 240 | - | expression tag |
| Pro 241 | - | expression tag |
| Gln 242 | - | expression tag |
| Phe 243 | - | expression tag |
| Glu 244 | - | expression tag |
| Lys 245 | - | expression tag |
| Ile 246 | - | expression tag |
| Glu 247 | - | expression tag |
| Gly 248 | - | expression tag |
| Arg 249 | - | expression tag |
| Ser 253 | Cys 253 | engineered mutation |
| Ser 384 | Cys 384 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 19502.5 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 906.2 | |
| All* | Total formula weight | 20408.7 |
