2XNO
Structure of Nek2 bound to CCT243779
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | SERINE/THREONINE-PROTEIN KINASE NEK2 | polymer | 279 | 32662.5 | 1 | UniProt (P51955) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | NEVER IN MITOSIS A-RELATED KINASE 2, NEK2, NIMA-RELATED PROTEIN KINASE 2, NIMA-LIKE PROTEIN KINASE 1, HSPK 21 |
| 2 | B (A) | 5-{6-[(1-methylpiperidin-4-yl)oxy]-1H-benzimidazol-1-yl}-3-{[2-(trifluoromethyl)benzyl]oxy}thiophene-2-carboxamide | non-polymer | 530.6 | 1 | Chemie (ED8) | |||
| 3 | C, D (A) | CHLORIDE ION | non-polymer | 35.5 | 2 | Chemie (CL) | |||
| 4 | E, F, G, H, I... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 11 | Chemie (EDO) | |||
| 5 | N (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | O (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) | |||
| 7 | R (A) | water | water | 18.0 | 207 | Chemie (HOH) |
Sequence modifications
A: 1 - 271 (UniProt: P51955)
| PDB | External Database | Details |
|---|---|---|
| Leu 272 | - | expression tag |
| Glu 273 | - | expression tag |
| His 274 | - | expression tag |
| His 275 | - | expression tag |
| His 276 | - | expression tag |
| His 277 | - | expression tag |
| His 278 | - | expression tag |
| His 279 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32662.5 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 1454.4 | |
| All* | Total formula weight | 34116.9 |
