2XNG
Structure of Aurora-A bound to a selective imidazopyrazine inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | SERINE/THREONINE-PROTEIN KINASE 6 | polymer | 283 | 32820.7 | 1 | UniProt (O14965) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | AURORA KINASE A, SERINE/THREONINE-PROTEIN KINASE AURORA-A, SERINE/THREONINE-PROTEIN KINASE 15, AURORA/IPL1-RELATED KINASE 1, BREAST TUMOR-AMPLIFIED KINASE, AURORA-RELATED KINASE 1, ARK-1, HARK1 |
| 2 | B (A) | N-(3-{3-chloro-8-[(4-morpholin-4-ylphenyl)amino]imidazo[1,2-a]pyrazin-6-yl}benzyl)methanesulfonamide | non-polymer | 513.0 | 1 | Chemie (A0H) | |||
| 3 | C (A) | water | water | 18.0 | 25 | Chemie (HOH) |
Sequence modifications
A: 122 - 403 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Met 121 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32820.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 513.0 | |
| All* | Total formula weight | 33333.7 |
