2XIJ

Crystal structure of human methylmalonyl-CoA mutase in complex with adenosylcobalamin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	METHYLMALONYL-COA MUTASE, MITOCHONDRIAL	polymer	762	84835.8	1	UniProt (P22033) Pfam (PF01642) Pfam (PF02310)	HOMO SAPIENS (HUMAN)	MCM, METHYLMALONYL-COA ISOMERASE
2	B (A)	5'-DEOXYADENOSINE	non-polymer		251.2	1	Chemie (5AD)
3	C, D (A)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4	E, F, G, H, I... (A)	1,2-ETHANEDIOL	non-polymer		62.1	8	Chemie (EDO)
5	L (A)	2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL	non-polymer		209.2	1	Chemie (BTB)
6	N (A)	COBALAMIN	non-polymer		1330.4	1	Chemie (B12)
7	O (A)	water	water		18.0	528	Chemie (HOH)

Sequence modifications

A: 12 - 750 (UniProt: P22033)

PDB	External Database	Details
Met 11	-	expression tag
Ala 751	-	expression tag
Glu 752	-	expression tag
Asn 753	-	expression tag
Leu 754	-	expression tag
Tyr 755	-	expression tag
Phe 756	-	expression tag
Gln 757	-	expression tag
Ser 758	-	expression tag
His 759	-	expression tag
His 760	-	expression tag
His 761	-	expression tag
His 762	-	expression tag
His 763	-	expression tag
His 764	-	expression tag
Asp 765	-	expression tag
Tyr 766	-	expression tag
Lys 767	-	expression tag
Asp 768	-	expression tag
Asp 769	-	expression tag
Asp 770	-	expression tag
Asp 771	-	expression tag
Lys 772	-	expression tag
Thr 499	Ala 499	variant

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	84835.8
Non-Polymers*	Number of molecules	13
	Total formula weight	2479.5
All*	Total formula weight	87315.3

*Water molecules are not included.