2XIJ
Crystal structure of human methylmalonyl-CoA mutase in complex with adenosylcobalamin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | METHYLMALONYL-COA MUTASE, MITOCHONDRIAL | polymer | 762 | 84835.8 | 1 | UniProt (P22033) Pfam (PF01642) Pfam (PF02310) | HOMO SAPIENS (HUMAN) | MCM, METHYLMALONYL-COA ISOMERASE |
| 2 | B (A) | 5'-DEOXYADENOSINE | non-polymer | 251.2 | 1 | Chemie (5AD) PubChem (16725083) PubChem (23638944) PubChem (25201172) PubChem (25796474) PubChem (25796475) PubChem (23615209) PubChem (40467849) PubChem (40467848) PubChem (676784) PubChem (6541038) PubChem (57115448) PubChem (59731278) PubChem (90321697) PubChem (121275112) PubChem (142) PubChem (71678) PubChem (124363198) PubChem (439182) PubChem (449044) PubChem (1277776) PubChem (6398669) PubChem (6928544) PubChem (12827542) PubChem (133636852) PubChem (140689696) PubChem (142801875) PubChem (142801934) | |||
| 3 | C, D (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | E, F, G, H, I... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 8 | Chemie (EDO) | |||
| 5 | L (A) | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 209.2 | 1 | Chemie (BTB) PubChem (81462) | |||
| 6 | N (A) | COBALAMIN | non-polymer | 1330.4 | 1 | Chemie (B12) | |||
| 7 | O (A) | water | water | 18.0 | 528 | Chemie (HOH) |
Sequence modifications
A: 12 - 750 (UniProt: P22033)
| PDB | External Database | Details |
|---|---|---|
| Met 11 | - | expression tag |
| Ala 751 | - | expression tag |
| Glu 752 | - | expression tag |
| Asn 753 | - | expression tag |
| Leu 754 | - | expression tag |
| Tyr 755 | - | expression tag |
| Phe 756 | - | expression tag |
| Gln 757 | - | expression tag |
| Ser 758 | - | expression tag |
| His 759 | - | expression tag |
| His 760 | - | expression tag |
| His 761 | - | expression tag |
| His 762 | - | expression tag |
| His 763 | - | expression tag |
| His 764 | - | expression tag |
| Asp 765 | - | expression tag |
| Tyr 766 | - | expression tag |
| Lys 767 | - | expression tag |
| Asp 768 | - | expression tag |
| Asp 769 | - | expression tag |
| Asp 770 | - | expression tag |
| Asp 771 | - | expression tag |
| Lys 772 | - | expression tag |
| Thr 499 | Ala 499 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 84835.8 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 2479.5 | |
| All* | Total formula weight | 87315.3 |
