2XBV
Factor Xa in complex with a pyrrolidine-3,4-dicarboxylic acid inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | ACTIVATED FACTOR XA HEAVY CHAIN | polymer | 241 | 27173.0 | 1 | UniProt (P00742) Pfam (PF00089) | HOMO SAPIENS (HUMAN) | |
| 2 | B (L) | FACTOR X LIGHT CHAIN | polymer | 55 | 6060.8 | 1 | UniProt (P00742) Pfam (PF14670) | HOMO SAPIENS (HUMAN) | |
| 3 | C (A) | (3R,4R)-1-(2,2-DIFLUORO-ETHYL)-PYRROLIDINE-3,4-DICARBOXYLIC ACID 3-[(5-CHLORO-PYRIDIN-2-YL)-AMIDE]-4-{[2-FLUORO-4-(2-OXO-2H-PYRIDIN-1-YL)-PHENYL]-AMIDE} | non-polymer | 519.9 | 1 | Chemie (XBV) | |||
| 4 | D (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | E (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | F, G (A, L) | water | water | 18.0 | 285 | Chemie (HOH) |
Sequence modifications
A: 16 - 251 (UniProt: P00742)
| PDB | External Database | Details |
|---|---|---|
| Glu 150 | Arg 372 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 33233.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 583.0 | |
| All* | Total formula weight | 33816.8 |
