2XB2
Crystal structure of the core Mago-Y14-eIF4AIII-Barentsz-UPF3b assembly shows how the EJC is bridged to the NMD machinery
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, K (A, X) | EUKARYOTIC INITIATION FACTOR 4A-III | polymer | 411 | 46931.0 | 2 | UniProt (P38919) Pfam (PF00270) Pfam (PF00271) | HOMO SAPIENS (HUMAN) | EIF4AIII, EUKARYOTIC TRANSLATION INITIATION FACTOR 4A ISOFORM 3, ATP-DEPENDENT RNA HELICASE EIF4A-3, ATP-DEPENDENT RNA HELICASE DDX48, DEAD BOX PROTEIN 48, EUKARYOTIC INITIATION FACTOR 4A-LIKE NUK-34, NUCLEAR MATRIX PROTEIN 265, NMP 265 |
| 2 | B, L (C, Y) | PROTEIN MAGO NASHI HOMOLOG | polymer | 146 | 17189.6 | 2 | UniProt (P61326) Pfam (PF02792) | HOMO SAPIENS (HUMAN) | MAGO |
| 3 | C, M (D, Z) | RNA-BINDING PROTEIN 8A | polymer | 90 | 10313.5 | 2 | UniProt (Q9Y5S9) Pfam (PF00076) | HOMO SAPIENS (HUMAN) | RNA-BINDING MOTIF PROTEIN 8A, Y14, RIBONUCLEOPROTEIN RBM8A, RNA-BINDING PROTEIN Y14, BINDER OF OVCA1-1, BOV-1 |
| 4 | D, G (E, R) | RNA POLY-U-RIBONUCLEOTIDE | polymer | 15 | 4547.5 | 2 | SYNTHETIC CONSTRUCT | ||
| 5 | E (F) | PUTATIVE REGULATOR OF NONSENSE TRANSCRIPTS 3B | polymer | 3 | 375.4 | 1 | UniProt (by SIFTS) (Q9BZI7) | HOMO SAPIENS (HUMAN) | |
| 6 | F, J (G, U) | REGULATOR OF NONSENSE TRANSCRIPTS 3B | polymer | 60 | 6809.5 | 2 | UniProt (Q9BZI7) | HOMO SAPIENS (HUMAN) | UPF3B, NONSENSE MRNA REDUCING FACTOR 3B, UP-FRAMESHIFT SUPPRESSOR 3 HOMOLOG B, UP-FRAMESHIFT SUPPRESSOR 3 HOMOLOG ON CHROMOSOME X, HUPF3P-X |
| 7 | H, I (S, T) | PROTEIN CASC3 | polymer | 150 | 17713.5 | 2 | UniProt (O15234) Pfam (PF09405) | HOMO SAPIENS (HUMAN) | BARENTSZ, CANCER SUSCEPTIBILITY CANDIDATE GENE 3 PROTEIN, METASTATIC LYMPH NODE GENE 51 PROTEIN, MLN 51, BTZ |
| 8 | N, P (A, X) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 9 | O, Q (A, X) | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | non-polymer | 506.2 | 2 | Chemie (ANP) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 13 |
| Total formula weight | 207384.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1061.0 | |
| All* | Total formula weight | 208445.6 |
