2XB2

Crystal structure of the core Mago-Y14-eIF4AIII-Barentsz-UPF3b assembly shows how the EJC is bridged to the NMD machinery

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, X	EUKARYOTIC INITIATION FACTOR 4A-III	polymer	411	46931.0	2	UniProt (P38919) Pfam (PF00270) Pfam (PF00271) In PDB	HOMO SAPIENS (HUMAN)	EIF4AIII, EUKARYOTIC TRANSLATION INITIATION FACTOR 4A ISOFORM 3, ATP-DEPENDENT RNA HELICASE EIF4A-3, ATP-DEPENDENT RNA HELICASE DDX48, DEAD BOX PROTEIN 48, EUKARYOTIC INITIATION FACTOR 4A-LIKE NUK-34, NUCLEAR MATRIX PROTEIN 265, NMP 265
2	C, Y	PROTEIN MAGO NASHI HOMOLOG	polymer	146	17189.6	2	UniProt (P61326) Pfam (PF02792) In PDB	HOMO SAPIENS (HUMAN)	MAGO
3	D, Z	RNA-BINDING PROTEIN 8A	polymer	90	10313.5	2	UniProt (Q9Y5S9) Pfam (PF00076) In PDB	HOMO SAPIENS (HUMAN)	RNA-BINDING MOTIF PROTEIN 8A, Y14, RIBONUCLEOPROTEIN RBM8A, RNA-BINDING PROTEIN Y14, BINDER OF OVCA1-1, BOV-1
4	E, R	RNA POLY-U-RIBONUCLEOTIDE	polymer	15	4547.5	2		SYNTHETIC CONSTRUCT
5	F	PUTATIVE REGULATOR OF NONSENSE TRANSCRIPTS 3B	polymer	3	375.4	1	UniProt (by SIFTS) (Q9BZI7) In PDB	HOMO SAPIENS (HUMAN)
6	G, U	REGULATOR OF NONSENSE TRANSCRIPTS 3B	polymer	60	6809.5	2	UniProt (Q9BZI7) In PDB	HOMO SAPIENS (HUMAN)	UPF3B, NONSENSE MRNA REDUCING FACTOR 3B, UP-FRAMESHIFT SUPPRESSOR 3 HOMOLOG B, UP-FRAMESHIFT SUPPRESSOR 3 HOMOLOG ON CHROMOSOME X, HUPF3P-X
7	S, T	PROTEIN CASC3	polymer	150	17713.5	2	UniProt (O15234) Pfam (PF09405) In PDB	HOMO SAPIENS (HUMAN)	BARENTSZ, CANCER SUSCEPTIBILITY CANDIDATE GENE 3 PROTEIN, METASTATIC LYMPH NODE GENE 51 PROTEIN, MLN 51, BTZ
8	A, X	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
9	A, X	PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER	non-polymer		506.2	2	Chemie (ANP)

Contents of the asymmetric unit

Polymers	Number of chains	13
	Total formula weight	207384.6
Non-Polymers*	Number of molecules	4
	Total formula weight	1061.0
All*	Total formula weight	208445.6

*Water molecules are not included.