2XA4
Inhibitors of Jak2 Kinase domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | TYROSINE-PROTEIN KINASE JAK2 | polymer | 298 | 35081.8 | 2 | UniProt (O60674) Pfam (PF07714) In PDB | Homo sapiens (Human) | JANUS KINASE 2, JAK-2 |
| 2 | A, B | 5-CHLORO-N2-[(1S)-1-(5-FLUOROPYRIMIDIN-2-YL)ETHYL]-N4-(5-METHYL-1H-PYRAZOL-3-YL)PYRIMIDINE-2,4-DIAMINE | non-polymer | 348.8 | 2 | Chemie (AZ5) | |||
| 3 | water | water | 18.0 | 308 | Chemie (HOH) |
Sequence modifications
A, B: 835 - 1132 (UniProt: O60674)
| PDB | External Database | Details |
|---|---|---|
| Ala 943 | Lys 943 | engineered mutation |
| Ala 945 | Lys 945 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 70163.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 697.5 | |
| All* | Total formula weight | 70861.1 |
