2X6S

Human foamy virus integrase - catalytic core. Magnesium-bound structure.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D, E... (A, B, C, D, E...)	INTEGRASE	polymer	200	22577.8	6	UniProt (P14350) Pfam (PF00665)	HUMAN SPUMARETROVIRUS	IN, P42IN
2	G, H, I, J, K... (A, B, C, D, E...)	MAGNESIUM ION	non-polymer		24.3	6	Chemie (MG)
3	M, N, O, P, Q... (A, B, C, D, E...)	water	water		18.0	267	Chemie (HOH)

Sequence modifications

A, B, C, D, E, F: 110 - 309 (UniProt: P14350)

PDB	External Database	Details
Met 127	Ile 878	engineered mutation
Arg 180	Lys 931	conflict
Met 227	Ile 978	engineered mutation
Met 253	Leu 1004	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	135466.8
Non-Polymers*	Number of molecules	6
	Total formula weight	145.8
All*	Total formula weight	135612.6

*Water molecules are not included.