2X2L

Crystal Structure of phosphorylated RET tyrosine kinase domain with inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET	polymer	314	35788.2	1	UniProt (P07949) Pfam (PF07714) In PDB	HOMO SAPIENS (HUMAN)	RET TYROSINE KINASE RECEPTOR, C-RET
2	A	FORMIC ACID	non-polymer		46.0	4	Chemie (FMT)
3	A	(3Z)-5-AMINO-3-[(4-METHOXYPHENYL)METHYLIDENE]-1,3-DIHYDRO-2H-INDOL-2-ONE	non-polymer		266.3	1	Chemie (X2L)
4		water	water		18.0	71	Chemie (HOH)

Sequence modifications

A: 700 - 704 (PDB: 2X2L)
A: 705 - 1013 (UniProt: P07949)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	35788.2
Non-Polymers*	Number of molecules	5
	Total formula weight	450.4
All*	Total formula weight	36238.6

*Water molecules are not included.