2WXV

Structure of CDK2-CYCLIN A with a Pyrazolo(4,3-h) quinazoline-3- carboxamide inhibitor

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	CELL DIVISION PROTEIN KINASE 2	polymer	309	35251.9	2	UniProt (P24941) Pfam (PF00069)	HOMO SAPIENS (HUMAN)	P33 PROTEIN KINASE
2	B, D (B, D)	CYCLIN-A2	polymer	265	30279.0	2	UniProt (P20248) Pfam (PF00134) Pfam (PF02984)	HOMO SAPIENS (HUMAN)	CYCLIN A2, CYCLIN-A
3	E, F (A, C)	N,1-DIMETHYL-8-{[1-(METHYLSULFONYL)PIPERIDIN-4-YL]AMINO}-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE	non-polymer		417.5	2	Chemie (WXV)
4	G (D)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
5	H, I, J, K (A, B, C, D)	water	water		18.0	140	Chemie (HOH)

Sequence modifications

A, C: -4 - 0 (PDB: 2WXV)
A, C: 299 - 304 (PDB: 2WXV)
A, C: 1 - 298 (UniProt: P24941)
B, D: 168 - 172 (PDB: 2WXV)
B, D: 173 - 432 (UniProt: P20248)

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	131061.7
Non-Polymers*	Number of molecules	3
	Total formula weight	931.0
All*	Total formula weight	131992.7

*Water molecules are not included.