2WTV
Aurora-A Inhibitor Structure
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | SERINE/THREONINE-PROTEIN KINASE 6 AURORA/IPL1-RELATED KINASE 1, BREAST TUMOR-AMPLIFIED KINASE, AURORA-A, AURORA-RELATED KINASE 1, HARK1 | polymer | 285 | 33228.9 | 4 | UniProt (O14965) Pfam (PF00069) In PDB | HOMO SAPIENS (HUMAN) | |
2 | D, A, B, C | 4-{[9-CHLORO-7-(2,6-DIFLUOROPHENYL)-5H-PYRIMIDO[5,4-D][2]BENZAZEPIN-2-YL]AMINO}BENZOIC ACID | non-polymer | 476.9 | 4 | Chemie (ZZL) | |||
3 | D, A, B, C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 11 | Chemie (EDO) | |||
4 | D, A, B, C | ACETATE ION | non-polymer | 59.0 | 9 | Chemie (ACT) | |||
5 | A, B | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
6 | water | water | 18.0 | 743 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 119 - 121 (PDB: 2WTV)
A, B, C, D: 122 - 403 (UniProt: O14965)
A, B, C, D: 122 - 403 (UniProt: O14965)
PDB | External Database | Details |
---|---|---|
Arg 215 | Leu 215 | engineered mutation |
Glu 217 | Thr 217 | engineered mutation |
Lys 220 | Arg 220 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 132915.6 | |
Non-Polymers* | Number of molecules | 26 |
Total formula weight | 3277.9 | |
All* | Total formula weight | 136193.4 |