2WQR
The high resolution crystal structure of IgE Fc
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | IG EPSILON CHAIN C REGION | polymer | 323 | 35930.3 | 2 | UniProt (P01854) Pfam (PF07654) | HOMO SAPIENS (HUMAN) | IMMUNOGLOBULIN E, IGE FC |
| 2 | C, D (C, D) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 2 | In PDB GlyTouCan (G22768VO) | |||
| 3 | E, F, G, L (A, B) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 4 | H, J (A, B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | I (A) | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL | non-polymer | 122.1 | 1 | Chemie (TRS) | |||
| 6 | K (B) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 7 | M, N (A, B) | water | water | 18.0 | 533 | Chemie (HOH) |
Sequence modifications
A, B: 225 - 546 (UniProt: P01854)
| PDB | External Database | Details |
|---|---|---|
| Gln 265 | Asn 146 | engineered mutation |
| Gln 371 | Asn 252 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 71860.6 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 1821.6 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 884.8 | |
| All* | Total formula weight | 74567.0 |
