2WQP
Crystal structure of sialic acid synthase NeuB-inhibitor complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | POLYSIALIC ACID CAPSULE BIOSYNTHESIS PROTEIN SIAC | polymer | 349 | 38880.7 | 1 | UniProt (Q7DDU0) Pfam (PF03102) Pfam (PF08666) | NEISSERIA MENINGITIDIS | SYNC PROTEIN, SIALIC ACID SYNTHASE |
| 2 | B (A) | 5-(ACETYLAMINO)-3,5-DIDEOXY-2-O-PHOSPHONO-D-ERYTHRO-L-MANNO-NONONIC ACID | non-polymer | 391.3 | 1 | Chemie (WQP) | |||
| 3 | C (A) | MANGANESE (II) ION | non-polymer | 54.9 | 1 | Chemie (MN) | |||
| 4 | D (A) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 5 | E, F, G, H (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 6 | I (A) | (2S)-2-hydroxybutanedioic acid | non-polymer | 134.1 | 1 | Chemie (LMR) | |||
| 7 | J (A) | water | water | 18.0 | 322 | Chemie (HOH) |
Sequence modifications
A: 1 - 349 (UniProt: Q7DDU0)
| PDB | External Database | Details |
|---|---|---|
| Leu 111 | Pro 111 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 38880.7 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 887.6 | |
| All* | Total formula weight | 39768.3 |
