2WPO

HCMV protease inhibitor complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	HUMAN CYTOMEGALOVIRUS PROTEASE	polymer	256	28178.7	4	UniProt (P16753) Pfam (PF00716)	Human herpesvirus 5 (Human cytomegalovirus)
2	E, F, G, H (A, B, C, D)	(2S)-2-(3,3-dimethylbutanoylamino)-N-[(2S)-1-[[(2S,3S)-3-hydroxy-4-[(4-iodophenyl)methylamino]-4-oxo-butan-2-yl]amino]- 1,4-dioxo-4-pyrrol-1-yl-butan-2-yl]-3,3-dimethyl-butanamide	non-polymer		709.6	4	BIRD (PRD_000229) Chemie (01E)

Sequence modifications

A, B, C, D: 1 - 256 (UniProt: P16753)

PDB	External Database	Details
Gln 143	Ala 143	engineered mutation
Met 181	Thr 181	engineered mutation
Met 229	Leu 229	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	112714.7
Non-Polymers*	Number of molecules	4
	Total formula weight	2838.5
All*	Total formula weight	115553.2

*Water molecules are not included.