2WO3

Crystal Structure of the EphA4-ephrinA2 complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	EPHRIN TYPE-A RECEPTOR	polymer	185	21467.2	1	UniProt (P54764) Pfam (PF01404)	Homo sapiens (Human)	TYROSINE-PROTEIN KINASE RECEPTOR SEK, RECEPTOR PROTEIN-TYROSINE KINASE HEK8, TYROSINE-PROTEIN KINASE TYRO1
2	B (B)	EPHRIN-A2	polymer	157	18065.1	1	UniProt (O43921) Pfam (PF00812)	Homo sapiens (Human)	EPH-RELATED RECEPTOR TYROSINE KINASE LIGAND 6, HEK7-LIGAND, LERK-6, HEK7-L
3	C (C)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	1	In PDB GlyTouCan (G42666HT)
4	D, E (A, B)	water	water		18.0	136	Chemie (HOH)

Sequence modifications

A: 30 - 202 (UniProt: P54764)

PDB	External Database	Details
Glu 27	-	expression tag
Thr 28	-	expression tag
Gly 29	-	expression tag
Arg 203	-	expression tag
Thr 204	-	expression tag
Lys 205	-	expression tag
His 206	-	expression tag
His 207	-	expression tag
His 208	-	expression tag
His 209	-	expression tag
His 210	-	expression tag
His 211	-	expression tag

B: 33 - 173 (UniProt: O43921)

PDB	External Database	Details
Glu 30	-	expression tag
Thr 31	-	expression tag
Gly 32	-	expression tag
Gln 174	Asn 174	engineered mutation
Glu 175	-	expression tag
Thr 176	-	expression tag
Leu 177	-	expression tag
Gly 178	-	expression tag
Thr 179	-	expression tag
Lys 180	-	expression tag
His 181	-	expression tag
His 182	-	expression tag
His 183	-	expression tag
His 184	-	expression tag
His 185	-	expression tag
His 186	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	39532.3
Branched	Number of molecules	1
	Total formula weight	424.4
All*	Total formula weight	39956.7

*Water molecules are not included.