2WKM
X-ray Structure of PHA-00665752 bound to the kinase domain of c-Met
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | HEPATOCYTE GROWTH FACTOR RECEPTOR | polymer | 306 | 34879.4 | 1 | UniProt (P08581) Pfam (PF07714) In PDB | HOMO SAPIENS (HUMAN) | HGF RECEPTOR, SCATTER FACTOR RECEPTOR, SF RECEPTOR, HGF/SF RECEPTOR, MET PROTO-ONCOGENE TYROSINE KINASE, C-MET |
| 2 | A | (3Z)-5-[(2,6-DICHLOROBENZYL)SULFONYL]-3-[(3,5-DIMETHYL-4-{[(2S)-2-(PYRROLIDIN-1-YLMETHYL)PYRROLIDIN-1-YL]CARBONYL}-1H-PYRROL-2-YL)METHYLIDENE]-1,3-DIHYDRO-2H-INDOL-2-ONE | non-polymer | 641.6 | 1 | Chemie (PFY) | |||
| 3 | water | water | 18.0 | 165 | Chemie (HOH) |
Sequence modifications
A: 1051 - 1348 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| Met 1050 | - | expression tag |
| His 1349 | - | expression tag |
| His 1350 | - | expression tag |
| His 1351 | - | expression tag |
| His 1352 | - | expression tag |
| His 1353 | - | expression tag |
| His 1354 | - | expression tag |
| His 1355 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34879.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 641.6 | |
| All* | Total formula weight | 35521.0 |
