2WJO

human Bace (beta secretase) in complex with Cyclohexanecarboxylic acid (2-(2-am ino-6-phenoxy-4H-quinazolin-3-yl)-2 -cyclohexyl-ethyl)- amide

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	BETA-SECRETASE 1	polymer	412	45991.7	1	UniProt (P56817) Pfam (PF00026) In PDB	HOMO SAPIENS (HUMAN)	BETA SECRETASE, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1, BETA-SITE APP CLEAVING ENZYME 1, MEMBRANE-ASSOCIATED ASPARTIC PROTEASE 2, MEMAPSIN-2, ASPARTYL PROTEASE 2, ASP 2, ASP2
2	A	2-AMINO-3-{(1R)-1-CYCLOHEXYL-2-[(CYCLOHEXYLCARBONYL)AMINO]ETHYL}-6-PHENOXYQUINAZOLIN-3-IUM	non-polymer		473.6	1	Chemie (QUD)
3		water	water		18.0	156	Chemie (HOH)

Sequence modifications

A: -3 - 399 (UniProt: P56817)

PDB	External Database	Details
Gly 400	-	expression tag
Asp 401	-	expression tag
Leu 402	-	expression tag
His 403	-	expression tag
His 404	-	expression tag
His 405	-	expression tag
His 406	-	expression tag
His 407	-	expression tag
His 408	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	45991.7
Non-Polymers*	Number of molecules	1
	Total formula weight	473.6
All*	Total formula weight	46465.3

*Water molecules are not included.