2WJO
human Bace (beta secretase) in complex with Cyclohexanecarboxylic acid (2-(2-am ino-6-phenoxy-4H-quinazolin-3-yl)-2 -cyclohexyl-ethyl)- amide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | BETA-SECRETASE 1 | polymer | 412 | 45991.7 | 1 | UniProt (P56817) Pfam (PF00026) | HOMO SAPIENS (HUMAN) | BETA SECRETASE, BETA-SITE AMYLOID PRECURSOR PROTEIN CLEAVING ENZYME 1, BETA-SITE APP CLEAVING ENZYME 1, MEMBRANE-ASSOCIATED ASPARTIC PROTEASE 2, MEMAPSIN-2, ASPARTYL PROTEASE 2, ASP 2, ASP2 |
| 2 | B (A) | 2-AMINO-3-{(1R)-1-CYCLOHEXYL-2-[(CYCLOHEXYLCARBONYL)AMINO]ETHYL}-6-PHENOXYQUINAZOLIN-3-IUM | non-polymer | 473.6 | 1 | Chemie (QUD) | |||
| 3 | C (A) | water | water | 18.0 | 156 | Chemie (HOH) |
Sequence modifications
A: -3 - 399 (UniProt: P56817)
| PDB | External Database | Details |
|---|---|---|
| Gly 400 | - | expression tag |
| Asp 401 | - | expression tag |
| Leu 402 | - | expression tag |
| His 403 | - | expression tag |
| His 404 | - | expression tag |
| His 405 | - | expression tag |
| His 406 | - | expression tag |
| His 407 | - | expression tag |
| His 408 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 45991.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 473.6 | |
| All* | Total formula weight | 46465.3 |
