2WIH

STRUCTURE OF CDK2-CYCLIN A WITH PHA-848125

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	CELL DIVISION PROTEIN KINASE 2	polymer	309	35251.9	2	UniProt (P24941) Pfam (PF00069)	HOMO SAPIENS (HUMAN)	P33 PROTEIN KINASE
2	B, D (B, D)	CYCLIN-A2	polymer	265	30279.0	2	UniProt (P20248) Pfam (PF00134) Pfam (PF02984)	HOMO SAPIENS (HUMAN)	CYCLIN A, CYCLIN A2
3	E, F (A, C)	N,1,4,4-TETRAMETHYL-8-{[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]AMINO}-4,5-DIHYDRO-1H-PYRAZOLO[4,3-H]QUINAZOLINE-3-CARBOXAMIDE	non-polymer		460.6	2	Chemie (P48)
4	G (D)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
5	H, I, J, K (A, B, C, D)	water	water		18.0	214	Chemie (HOH)

Sequence modifications

A, C: 1 - 298 (UniProt: P24941)

PDB	External Database	Details
Gly -4	-	expression tag
Pro -3	-	expression tag
Leu -2	-	expression tag
Val -1	-	expression tag
Asp 0	-	expression tag
Glu 299	-	expression tag
Arg 300	-	expression tag
Pro 301	-	expression tag
His 302	-	expression tag
Arg 303	-	expression tag
Asp 304	-	expression tag

B, D: 173 - 432 (UniProt: P20248)

PDB	External Database	Details
Gly 168	-	expression tag
Pro 169	-	expression tag
Leu 170	-	expression tag
Gly 171	-	expression tag
Ser 172	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	131061.7
Non-Polymers*	Number of molecules	3
	Total formula weight	1017.2
All*	Total formula weight	132078.9

*Water molecules are not included.