2WGJ
X-ray Structure of PF-02341066 bound to the kinase domain of c-Met
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | HEPATOCYTE GROWTH FACTOR RECEPTOR | polymer | 306 | 34879.4 | 1 | UniProt (P08581) Pfam (PF07714) | HOMO SAPIENS (HUMAN) | HGF RECEPTOR, SCATTER FACTOR RECEPTOR, SF RECEPTOR, HGF/SF RECEPTOR, MET PROTO-ONCOGENE TYROSINE KINASE, C-MET |
| 2 | B (A) | 3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine | non-polymer | 450.3 | 1 | Chemie (VGH) | |||
| 3 | C (A) | water | water | 18.0 | 180 | Chemie (HOH) |
Sequence modifications
A: 1050 - 1050 (PDB: 2WGJ)
A: 1349 - 1355 (PDB: 2WGJ)
A: 1051 - 1348 (UniProt: P08581)
A: 1349 - 1355 (PDB: 2WGJ)
A: 1051 - 1348 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| Leu 1272 | Val 1272 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34879.4 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 450.3 | |
| All* | Total formula weight | 35329.8 |
