2WGJ

X-ray Structure of PF-02341066 bound to the kinase domain of c-Met

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	HEPATOCYTE GROWTH FACTOR RECEPTOR	polymer	306	34879.4	1	UniProt (P08581) Pfam (PF07714) In PDB	HOMO SAPIENS (HUMAN)	HGF RECEPTOR, SCATTER FACTOR RECEPTOR, SF RECEPTOR, HGF/SF RECEPTOR, MET PROTO-ONCOGENE TYROSINE KINASE, C-MET
2	A	3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)pyridin-2-amine	non-polymer		450.3	1	Chemie (VGH)
3		water	water		18.0	180	Chemie (HOH)

Sequence modifications

A: 1050 - 1050 (PDB: 2WGJ)
A: 1349 - 1355 (PDB: 2WGJ)
A: 1051 - 1348 (UniProt: P08581)

PDB	External Database	Details
Leu 1272	Val 1272	conflict

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	34879.4
Non-Polymers*	Number of molecules	1
	Total formula weight	450.3
All*	Total formula weight	35329.8

*Water molecules are not included.