2WEV

Truncation and Optimisation of Peptide Inhibitors of CDK2, Cyclin A Through Structure Guided Design

Replaces:  2C5P

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C (A, C)	CELL DIVISION PROTEIN KINASE 2	polymer	298	33976.5	2	UniProt (P24941) Pfam (PF00069)	HOMO SAPIENS (HUMAN)	CYCLIN-DEPENDENT KINASE 2, P33 PROTEIN KINASE
2	B, D (B, D)	CYCLIN-A2	polymer	260	29867.5	2	UniProt (P20248) Pfam (PF00134) Pfam (PF02984)	HOMO SAPIENS (HUMAN)	CYCLIN-A
3	E, F (E, F)	ARG-ARG-B3L-MEA	polymer	6	644.8	2		SYNTHETIC CONSTRUCT
4	G, H (A, C)	[4-(2-AMINO-4-METHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-(3-NITRO-PHENYL)-AMINE	non-polymer		328.3	2	Chemie (CK7)
5	I, J, K, L (A, B, C, D)	water	water		18.0	545	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	128977.7
Non-Polymers*	Number of molecules	2
	Total formula weight	656.7
All*	Total formula weight	129634.4

*Water molecules are not included.