2WAH
Crystal Structure of an IgG1 Fc Glycoform (Man9GlcNAc2)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | IG GAMMA-1 CHAIN C REGION | polymer | 209 | 23701.8 | 2 | UniProt (P01857) Pfam (PF07654) | Homo sapiens (Human) | IGG1 FC |
| 2 | C (C) | alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1559.4 | 1 | In PDB GlyTouCan (G83161QT) | |||
| 3 | D (D) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 4 | E, F (A, B) | water | water | 18.0 | 94 | Chemie (HOH) |
Sequence modifications
A, B: 237 - 445 (UniProt: P01857)
| PDB | External Database | Details |
|---|---|---|
| Ala 393 | Thr 276 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 47403.5 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 2145.9 | |
| All* | Total formula weight | 49549.5 |
