2W9Z

Crystal Structure of CDK4 in complex with a D-type cyclin

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	G1/S-SPECIFIC CYCLIN-D1	polymer	257	29276.3	1	UniProt (P24385) Pfam (PF00134) Pfam (PF02984)	HOMO SAPIENS (HUMAN)	PRAD1 ONCOGENE, BCL-1 ONCOGENE, D-TYPE CYCLIN
2	B (B)	CELL DIVISION PROTEIN KINASE 4	polymer	306	34544.6	1	UniProt (P11802) Pfam (PF00069)	HOMO SAPIENS (HUMAN)	CYCLIN-DEPENDENT KINASE 4, PSK-J3, CDK4
3	C, D (A, B)	water	water		18.0	222	Chemie (HOH)

Sequence modifications

A: 15 - 15 (PDB: 2W9Z)
A: 16 - 271 (UniProt: P24385)
B: 1 - 44 (UniProt: P11802)

PDB	External Database	Details
Glu 43	Gly 43	engineered mutation
Glu 44	Gly 44	engineered mutation

B: 48 - 303 (UniProt: P11802)

PDB	External Database	Details
Ala 172	Thr 172	engineered mutation

B: 304 - 309 (PDB: 2W9Z)

Sequence viewer

Contents of the asymmetric unit

*Water molecules are not included.