2W96
Crystal Structure of CDK4 in complex with a D-type cyclin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | G1/S-SPECIFIC CYCLIN-D1 | polymer | 271 | 30990.3 | 1 | UniProt (P24385) Pfam (PF00134) Pfam (PF02984) | HOMO SAPIENS (HUMAN) | D-TYPE CYCLIN, PRAD1 ONCOGENE |
| 2 | B (B) | CELL DIVISION PROTEIN KINASE 4 | polymer | 306 | 34588.6 | 1 | UniProt (P11802) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | CDK4, CYCLIN-DEPENDENT KINASE 4, PSK-J3 |
| 3 | C (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 190 | Chemie (HOH) |
Sequence modifications
B: 1 - 44 (UniProt: P11802)
B: 48 - 303 (UniProt: P11802)
B: 304 - 309 (PDB: 2W96)
| PDB | External Database | Details |
|---|---|---|
| Glu 43 | Gly 43 | engineered mutation |
| Glu 44 | Gly 44 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asp 172 | Thr 172 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65578.9 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 92.1 | |
| All* | Total formula weight | 65671.0 |
