2W3K
Crystal Structure of FXa in complex with 4,4-disubstituted pyrrolidine-1,2-dicarboxamide inhibitor 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | COAGULATION FACTOR X, HEAVY CHAIN | polymer | 234 | 26447.1 | 1 | UniProt (P00742) Pfam (PF00089) | HOMO SAPIENS (HUMAN) | ACTIVATED FACTOR XA, STUART FACTOR, STUART-PROWER FACTOR |
| 2 | B (B) | COAGULATION FACTOR X, LIGHT CHAIN | polymer | 51 | 5460.1 | 1 | UniProt (P00742) Pfam (PF14670) | HOMO SAPIENS (HUMAN) | ACTIVATED FACTOR XA, STUART FACTOR, STUART-PROWER FACTOR |
| 3 | C (A) | (2R,4S)-N^1^-(4-chlorophenyl)-N^2^-[2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl]-4-hydroxy-4-phenylpyrrolidine-1,2-dicarboxamide | non-polymer | 547.0 | 1 | Chemie (L1D) | |||
| 4 | D (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 121 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 31907.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 587.1 | |
| All* | Total formula weight | 32494.2 |
