2VWX
ephB4 kinase domain inhibitor complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | EPHRIN TYPE-B RECEPTOR 4 | polymer | 302 | 33934.8 | 1 | UniProt (P54760) Pfam (PF07714) | HOMO SAPIENS (HUMAN) | EPHB4 RECEPTOR TYROSINE KINASE, TYROSINE-PROTEIN KINASE RECEPTOR HTK, TYROSINE-PROTEIN KINASE TYRO11 |
| 2 | B (A) | 3-({4-[(5-chloro-1,3-benzodioxol-4-yl)amino]pyrimidin-2-yl}amino)benzenesulfonamide | non-polymer | 419.8 | 1 | Chemie (7X4) | |||
| 3 | C, D, E, F (A) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 4 | G (A) | water | water | 18.0 | 274 | Chemie (HOH) |
Sequence modifications
A: 598 - 899 (UniProt: P54760)
| PDB | External Database | Details |
|---|---|---|
| Glu 774 | Tyr 774 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 33934.8 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 517.1 | |
| All* | Total formula weight | 34451.9 |
